MSA 815182 GME-P100 Multigas / P100 Cartridge for Comfo Respirators — Box of 6

MSA GME-P100 Overview

The MSA GME-P100 is a NIOSH-approved combination cartridge that simultaneously protects against nine inorganic and reactive gas hazard classes — chlorine, sulfur dioxide, chlorine dioxide, hydrogen chloride, hydrogen sulfide, ammonia, methylamine, formaldehyde, and hydrogen fluoride — plus P100 particulate filtration, all in a single bayonet-mount unit designed for the MSA Comfo-series respirator platform. Each box contains 6 cartridges (SKU 815182) priced at $189.43/box, working out to $31.57 per cartridge — a cost-competitive rate given the breadth of hazards addressed without stacking separate cartridges.

Before purchasing, confirm your specific hazard profile against the respirator cartridge selection guide and review how different filter types are constructed. If your hazard list includes organic vapors, compare this cartridge against the GMC-P100 before deciding. All MSA Comfo cartridges are listed at MSA Respirator Filters & Cartridges.

Affiliate disclosure: WC Safety earns a commission on Amazon purchases at no cost to you.

Where the GME-P100 Fits in Respirator Selection

Cartridge selection starts with the hazard — not the respirator. Before mounting any cartridge, identify every contaminant present in your work atmosphere, then match each to an approved filter class. The GME-P100 belongs in your shortlist when your industrial hygienist or SDS review confirms the presence of two or more of the following: inorganic acids (chlorine, HCl, SO₂, ClO₂), hydrogen sulfide, ammonia or methylamine, formaldehyde, or hydrogen fluoride — along with particulate hazards such as silica, weld fume, or fibers.

If your atmosphere contains only acid gases without the ammonia/methylamine/formaldehyde component, the narrower GMB-P100 Acid Gas/P100 cartridge may offer equivalent protection at a lower cost. If organic vapors are also present, step up to the GMC-P100. For detailed decision logic, work through the how-to-choose-a-respirator-cartridge guide and consult the respirator cartridge color-code chart to verify label markings against NIOSH designations.

Who Should Buy the GME-P100?

Buy the GME-P100 if:

• Your workplace atmosphere involves three or more distinct inorganic/reactive gas hazards simultaneously (e.g., wastewater treatment plants where chlorine, H₂S, and ammonia co-exist).
• You already own an MSA Comfo Classic, Comfo II, Ultra-Twin, or Ultra-Elite full-face respirator and need a multi-hazard cartridge on that platform.
• Particulate hazards (respirable silica, metal fume, asbestos, fibers) are present alongside the gas hazards — the integrated P100 layer eliminates the need for a separate pre-filter.
• Your SDS or IH assessment identifies formaldehyde or hydrogen fluoride — hazards not covered by the standard GME multi-gas cartridge without P100.

Do not buy the GME-P100 if:

• Organic vapors (solvents, VOCs, hydrocarbons) are the primary hazard — choose the GMC-P100 OV/Acid Gas/P100 or the GMA-P100 OV/P100 instead.
• You are using an MSA Advantage-series half-mask — those respirators use a snap-on connection system that is not compatible with Comfo-series bayonet cartridges.
• The work environment is oxygen-deficient or classified IDLH — supplied-air or SCBA is required regardless of cartridge rating.
• Your hazard is particulate-only — the MSA Low-Profile P100 filter will work without the chemical sorbent cost.

What Does the GME-P100 Protect Against?

The nine confirmed hazard classes covered by the GME-P100 per MSA published specifications:

What the GME-P100 Does NOT Protect Against

• Organic vapors (OV) — the GME-P100 contains no activated carbon OV sorbent bed. Solvents, hydrocarbons, ketones, and other VOCs pass through. If OV protection is needed alongside multi-gas coverage, the GMC-P100 adds an OV sorbent layer.
• Mercury vapor — requires a specialized impregnated charcoal cartridge; see the MSA Mersorb P100 Mercury Vapor cartridge.
• Radioactive particulate and highly toxic particulars — while P100 at ≥99.97% is the highest NIOSH class, always verify specific contaminant protocols with your health and safety authority.
• Carbon monoxide, nitrogen dioxide, and other IDLH gases — no air-purifying cartridge protects against these at high concentrations.
• Iodine and radioiodine — requires the MSA GMI Iodine/P100 cartridge.

Best Applications for the GME-P100

Wastewater Treatment & Water Utilities

Municipal and industrial wastewater facilities routinely produce chlorine (from disinfection), H₂S (from anaerobic decomposition), and ammonia — all simultaneously. The GME-P100 is purpose-matched to this co-exposure scenario. The integrated P100 layer also handles bioaerosols and fine particulate from dewatering operations. Pair with an MSA Ultra-Elite or Ultra-Twin full-face respirator for eye protection in chlorine atmospheres.

Pulp & Paper / Bleaching Operations

Kraft pulping and chlorine-dioxide bleaching sequences generate SO₂, ClO₂, HCl, and H₂S. The GME-P100's coverage of chlorine dioxide specifically — a hazard many combination cartridges omit — makes it one of the most specified choices in this industry. Review the filter type construction guide to understand why multi-bed sorbent architecture is necessary for this hazard mix.

Semiconductor & Electronics Manufacturing

Wet-etch processes in chip fabrication use hydrofluoric acid (HF), and diffusion furnaces can generate HCl and formaldehyde from process gases. The GME-P100's HF and formaldehyde coverage fills a gap left by standard acid-gas cartridges. Because particulate contamination is also critical in cleanroom environments, the P100 layer provides simultaneous protection. Consult the cartridge selection guide to verify concentration limits against your process SDS.

Chemical Processing & Laboratory Environments

Chemical plants, ammonia refrigeration facilities, formaldehyde-handling labs (pathology, embalming, histology), and industrial cleaning operations that use multiple reactive chemicals benefit from the nine-hazard coverage in a single cartridge. For formaldehyde-specific guidance, note that formaldehyde is also a suspected carcinogen — confirm your facility's OSHA PEL/STEL against the cartridge's rated service life via your IH. Browse the full MSA Comfo cartridge lineup to compare specialty options.

Pros & Cons

Compatible MSA Respirators

The GME-P100 uses the MSA Comfo/GM-series threaded bayonet mount. Confirm your facepiece model before ordering.

GME-P100 vs Other MSA Comfo Filters and Cartridges

All cartridges below use the MSA Comfo bayonet mount. This comparison covers the combination (gas + P100) cartridge subset.

GME-P100 vs GME Multi-Gas (No P100)

The GME multi-gas cartridge without P100 covers identical gas hazards — chlorine, SO₂, ClO₂, HCl, H₂S, ammonia, methylamine, formaldehyde, and HF — but omits the P100 particulate layer. Choose the GME (no P100) only when your atmosphere is confirmed gas-only and free of respirable particulate. In most industrial environments with reactive gas hazards, co-exposure to particulate (silica from abrasive operations, metal fume from cutting, dust from material handling) is common; the GME-P100 eliminates the need to change out separately purchased pre-filters and reduces user error from forgetting the particulate layer.

GME-P100 vs GMB-P100 Acid Gas/P100

The GMB-P100 Acid Gas/P100 covers the inorganic acid-gas subset (Cl₂, SO₂, HCl, H₂S, HF) with the same P100 particulate layer, but does not include the ammonia/methylamine or formaldehyde sorbent beds. If your SDS confirms the absence of ammonia, methylamine, and formaldehyde — and your hazard profile is purely inorganic acid gases plus particulate — the GMB-P100 provides equivalent protection at a typically lower cost per cartridge. The GME-P100 is the right choice when ammonia, methylamine, or formaldehyde are confirmed or probable co-exposures.

MSA GME-P100 Quick Answers

Does the GME-P100 protect against organic vapors?

No. The GME-P100 contains no activated carbon OV sorbent bed and is not rated for organic vapor protection. Workers exposed to solvents, VOCs, hydrocarbons, or other organic vapors should select the MSA GMC-P100 OV/Acid Gas/P100 cartridge, which adds an OV sorbent layer to the acid-gas and P100 protection.

What respirators does the GME-P100 fit?

The GME-P100 uses the MSA Comfo/GM-series threaded bayonet mount and is compatible with the Comfo Classic, Comfo II, Ultra-Twin, and Ultra-Elite full-face respirators. It does not fit MSA Advantage-series snap-on respirators or any non-MSA brand respirator.

How many cartridges come in a box and what is the per-unit cost?

Each box contains 6 cartridges. At the current price of $189.43 per box, the per-cartridge cost is $31.57. For crew or shift deployments, this box format is more cost-effective than purchasing individual cartridges from other sources.

Does the GME-P100 cover both ammonia and hydrogen sulfide at the same time?

Yes. The GME-P100 includes sorbent beds rated for both ammonia (and methylamine) and hydrogen sulfide, which makes it particularly well-suited for wastewater treatment environments where both gases are simultaneously present. This dual coverage in a single cartridge is one of its primary advantages over narrower combination cartridges.

Is the P100 rating the highest available for particulate filtration?

Yes. NIOSH P100 designates a filter efficiency of ≥99.97% against oil-based and non-oil-based aerosols, making it the highest particulate filtration class in the NIOSH 42 CFR 84 classification system. The "P" prefix indicates it is also oil-proof, meaning it maintains efficiency in oily mist environments — relevant in some chemical processing contexts. For a full breakdown of N, R, and P filter classes, see the respirator filter types guide.

Can I use the GME-P100 in a confined space?

Only if the confined space atmosphere has been tested, confirmed non-IDLH, and confirmed above 19.5% oxygen by a qualified person before entry. Air-purifying cartridges — including the GME-P100 — cannot be used in oxygen-deficient atmospheres or IDLH conditions. Confined spaces that have not been tested must be treated as IDLH until proven otherwise, requiring SCBA or supplied-air equipment.

How does the multi-layer construction work?

The GME-P100 uses a multi-bed sorbent architecture: air enters through the P100 particulate filter at the inlet (capturing fine particles first), then passes sequentially through chemically impregnated sorbent layers targeting each gas hazard class — acid-gas sorbent for Cl₂/SO₂/HCl/ClO₂/HF, an ammonia/methylamine sorbent bed, and a formaldehyde-specific impregnated layer. Each bed is sized and positioned to maximize service life for its target contaminant. Review the organic vapor vs P100 construction comparison to understand how this differs from OV-type cartridges.

MSA GME-P100 Specifications

Helpful Buying Guides

• How to Choose a Respirator Cartridge — Step-by-Step Selection Guide
• Respirator Filter Types Explained — N95, P100, OV, AG, and Combination
• Organic Vapor vs P100 — When to Use Each Filter Type
• Respirator Cartridge Color Code Chart — NIOSH Label Guide
• Best Respirator for Silica Dust (2026) — Ratings & Buyer Guide
• Best Respirator for Welding Fumes — Selection & Filter Guide

MSA GME-P100 Frequently Asked Questions

What is the difference between the GME-P100 and the GME cartridge?

Both cartridges cover the same nine inorganic and reactive gas hazard classes. The GME-P100 adds an integrated P100 particulate filter (≥99.97% efficiency) at the inlet, making it a true combination cartridge. The GME without P100 is a gas-sorbent-only cartridge for atmospheres confirmed to be free of respirable particulate.

Is the GME-P100 rated for hydrogen sulfide?

Yes. Hydrogen sulfide (H₂S) is one of the nine gas hazard classes covered by the GME-P100 per MSA published specifications. This makes it appropriate for wastewater treatment, oil and gas, and confined-space rescue preparedness where H₂S is a documented co-hazard alongside chlorine, ammonia, or other inorganic gases.

How often should I change the GME-P100 cartridge?

Cartridge service life depends on contaminant concentration, breathing rate, humidity, and temperature — factors that vary significantly by worksite. OSHA requires employers to establish a written cartridge change-out schedule based on industrial hygiene data or NIOSH cartridge service-life model outputs. A best practice: change cartridges at the end of each shift in high-concentration environments, and immediately if any odor or taste breakthrough is detected regardless of schedule.

Can the GME-P100 be used with the MSA Ultra-Elite full-face respirator?

Yes. The MSA Ultra-Elite full-face respirator uses the MSA Comfo/GM-series bayonet connection system, which is directly compatible with the GME-P100. The Ultra-Elite accepts two cartridges — one on each side — so two GME-P100 cartridges are required per respirator per change-out interval.

Does the GME-P100 protect against formaldehyde?

Yes. Formaldehyde protection requires a specialized impregnated sorbent bed that is not present in standard organic-vapor or acid-gas cartridges. The GME-P100 includes a formaldehyde-rated sorbent layer, making it appropriate for pathology labs, embalming facilities, histology, and industrial processes that use formaldehyde resins. Verify concentration limits against your specific work atmosphere with your industrial hygienist before relying on this cartridge for OSHA-regulated formaldehyde exposures.

Is the GME-P100 suitable for welding fume?

The integrated P100 layer provides protection against metal fume particulate generated during welding. However, welding also generates manganese fume, ozone, and nitrogen dioxide — none of which are covered by the GME-P100's gas sorbent beds. Review the welding fume respirator guide to assess whether the GME-P100's hazard coverage matches your welding process, or whether a different cartridge or a powered air-purifying respirator (PAPR) is more appropriate.

How do I store unused GME-P100 cartridges?

Store cartridges sealed in their original packaging in a cool, dry environment away from sources of contamination (solvents, gases, chemicals) until ready for use. Sorbent materials can become saturated from ambient exposure even before fitting to a respirator. Check the manufacturer's stated shelf life and inspect packaging for damage before issuing cartridges from storage. Do not store open cartridges on a respirator between uses in contaminated atmospheres.

Can I use just one GME-P100 cartridge on a dual-cartridge full-face respirator?

No. Dual-port respirators such as the Ultra-Twin and Ultra-Elite require a matched cartridge installed on both ports. Using only one cartridge leaves the second port unsealed or improperly loaded, which compromises the face seal and protection factor. Always install a matched pair of cartridges simultaneously on dual-port respirators.

Does WC Safety sell individual GME-P100 cartridges, or only the box of 6?

The GME-P100 is listed as a box of 6 cartridges (SKU 815182). Individual cartridge sales are not available through this listing. The box format offers cost savings for teams and is appropriate for scheduled maintenance programs. For bulk orders, contact WC Safety directly. For immediate single-quantity availability, check the Amazon listing linked above.

What is the part number for the GME-P100?

The MSA part number is 815182. Use this number when ordering through procurement systems, referencing your MSDS, or cross-referencing against your facility's approved product list. The GTIN/barcode is 641817011089.

Are there other MSA Comfo cartridges I should compare before buying?

Yes — the right cartridge depends on your specific hazards. Key alternatives on the same bayonet mount include the GMA-P100 for organic vapors with particulate, the GMB-P100 for acid-gas-only environments with particulate, and the GMC-P100 for combined OV and acid-gas hazards with particulate. The full range is listed at MSA Respirator Filters & Cartridges.

Does the GME-P100 work with 3M or Moldex respirators?

No. Respirator cartridges are not interchangeable across brands — NIOSH approvals are issued for specific respirator/cartridge combinations. The GME-P100 is approved for use on MSA Comfo-series bayonet-mount respirators only. Workers using 3M respirators should consult the 3M respirator filters and cartridges category, and Moldex users should look at Moldex respirator cartridges and filters.